| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 02/10/25 18:45 | Rayo Vallecano | KF Shkendija | --- |
| 02/10/25 18:45 | Jagiellonia Bialystok | Hamrun Spartans | --- |
| 02/10/25 18:45 | Lech Poznan | SK Rapid Wien | --- |
| 02/10/25 18:45 | Omonia Nicosia | FSV Mayence 05 | --- |
| 02/10/25 18:45 | FC Noah | HNK Rijeka | --- |
| 02/10/25 18:45 | FC Lausanne-Sport | Breidablik Kopavogur | --- |
| 02/10/25 18:45 | HŠK Zrinjski Mostar | Lincoln Red Imps FC | --- |
| 02/10/25 18:45 | Kuopion PS | KF Drita Gjilan | --- |
| 02/10/25 18:45 | Dynamo Kiew | Crystal Palace | --- |
| 02/10/25 21:00 | NK Celje | AEK Athènes | --- |
| 02/10/25 21:00 | FC Shelbourne | BK Häcken | --- |
| 02/10/25 21:00 | AEK Larnaka | AZ Alkmaar | --- |
| 02/10/25 21:00 | FC Aberdeen | Shakhtar Donetsk | --- |
| 02/10/25 21:00 | KS Rakow Czestochowa | Universitatea Craiova | --- |
| 02/10/25 21:00 | Sparta Prag | Shamrock Rovers | --- |
| 02/10/25 21:00 | SK Slovan Bratislava | Racing Club Strasbourg | --- |
| 02/10/25 21:00 | Legia Warschau | Samsunspor | --- |
| 02/10/25 21:00 | AC Florenz | Sigma Olomouc | --- |